OTC
Antihistamine (sedating)
Promethazine
Last reviewed April 2026
Who is this for?
What is this drug?
Promethazine is an antihistamine drug that works by blocking a chemical called histamine in your body, which helps stop allergic reactions, nausea, vomiting, and also makes you feel sleepy.
What is it used for?
Allergies (sneezingitchingwatery eyesskin rash)nausea and vomitingmotion sickness (travel sickness)trouble sleepingcough and cold symptoms
Available Over The Counter
Available at pharmacies without a prescription. Rules may vary by country.