OTC

Antihistamine (sedating)

Promethazine

Last reviewed April 2026

Who is this for?

What is this drug?

Promethazine is an antihistamine drug that works by blocking a chemical called histamine in your body, which helps stop allergic reactions, nausea, vomiting, and also makes you feel sleepy.

What is it used for?

Allergies (sneezingitchingwatery eyesskin rash)nausea and vomitingmotion sickness (travel sickness)trouble sleepingcough and cold symptoms

Available Over The Counter

Available at pharmacies without a prescription. Rules may vary by country.

Quick Interaction Check

Is Promethazine safe to take with another drug?

Check with multiple drugs →