Antihistamine (sedating)
Last reviewed April 2026
Who is this for?
Diphenhydramine is an antihistamine that works by blocking a natural substance called histamine in your body. It reduces allergic reactions, helps you sleep, and can calm coughing by acting on the brain's cough and sleep centers.
Available Over The Counter
Get this from any pharmacy or chemist — no prescription needed.
Is Diphenhydramine safe to take with another drug?
Check with multiple drugs →Explore this drug