Antidepressant (SSRI — Selective Serotonin Reuptake Inhibitor)
Last reviewed June 2026
Who is this for?
Fluoxetine is a medicine that works by increasing a natural chemical called serotonin in your brain, which helps improve your mood, energy, and feelings of well-being.
Inhibits the reuptake of serotonin at the presynaptic nerve terminal by blocking the serotonin transporter (SERT), increasing synaptic serotonin concentrations and enhancing serotonergic neurotransmission. This restoration of serotonin activity alleviates symptoms of depression, anxiety, and related mood and obsessive-compulsive disorders.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
Usually you start with one 20 mg capsule once a day, taken in the morning. You can take it with or without food, but taking it with food may reduce stomach upset. Your doctor may increase the dose over time, but do not change the dose yourself. It may take 2 to 4 weeks before you start feeling better, so do not stop taking it because you think it is not working.
If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed one and continue your normal schedule. Do not take two capsules at once to make up for a missed dose.
This is a prescription medicine — do not buy it from roadside sellers or take it because someone recommended it; you need a proper doctor's assessment first. Do not suddenly stop taking fluoxetine on your own as it can cause withdrawal symptoms like dizziness, anxiety, and irritability — your doctor should gradually reduce your dose. Do not share this medicine with others even if they seem to have similar symptoms, as it can be dangerous for them.
Do not take fluoxetine with MAO inhibitor drugs (sometimes used for depression or Parkinson's disease) — the combination can be life-threatening. Avoid mixing with tramadol or other strong painkillers as it can cause a dangerous condition called serotonin syndrome (symptoms include confusion, fast heartbeat, and muscle twitching). Avoid alcohol while taking fluoxetine as it can worsen drowsiness and affect your mood.
Check your specific combination
Is it safe to take Fluoxetine with your other drugs?
Fluoxetine is not considered safe during pregnancy or breastfeeding unless your doctor specifically says the benefit outweighs the risk — always consult your doctor before taking it if you are pregnant, planning to become pregnant, or breastfeeding.
Store in a cool, dry place away from direct sunlight and heat — this is important in Nigeria's hot climate. Keep the capsules in their original container and always store out of reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Dispensing Fluoxetine?
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