Antidepressant (SSRI — Selective Serotonin Reuptake Inhibitor)
Last reviewed June 2026
Who is this for?
Paroxetine is a medicine that works by increasing a natural chemical called serotonin in the brain, which helps improve your mood, reduce worry, and make you feel calmer.
Inhibits the reuptake of serotonin at the presynaptic nerve terminal by binding to the serotonin transporter (SERT), increasing synaptic serotonin concentration and enhancing serotonergic neurotransmission. This increased serotonin availability in the central nervous system alleviates symptoms of depression, anxiety, and related psychiatric conditions.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
Usually you start with one 20mg tablet taken once a day in the morning. Your doctor may increase it gradually up to 50mg depending on your condition. Take it with food to reduce stomach upset. Swallow the tablet whole with water — do not crush or chew it.
If you miss a dose, take it as soon as you remember — but if it is almost time for your next dose, skip the missed one and continue as normal. Do not take two tablets at once to make up for the missed dose.
Do not stop taking paroxetine suddenly — cutting it off without your doctor's guidance can cause withdrawal symptoms like dizziness, electric shock feelings, and irritability. Only buy from a licensed pharmacy, not roadside vendors, as fake or expired versions are dangerous. This is a personal prescription medicine — do not share it with friends or family members who say they feel depressed.
Do not take paroxetine with MAO inhibitor drugs (like selegiline or phenelzine) — this combination can be life-threatening. Avoid mixing with tramadol or other strong painkillers as it can cause dangerous side effects. Alcohol makes the drowsiness and dizziness much worse, so it is best to avoid drinking while on this medicine.
Check your specific combination
Is it safe to take Paroxetine with your other drugs?
Paroxetine is not safe during pregnancy, especially in the first three months, as it may cause birth defects; it also passes into breast milk, so talk to your doctor before using it if you are pregnant, planning to become pregnant, or breastfeeding.
Store in a cool, dry place away from direct sunlight and heat — Nigeria can be very hot, so do not leave it in your car or near a window. Keep the tablets in their original pack and far away from children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.