Painkiller and anti-inflammatory (NSAID + Analgesic combination)
Last reviewed June 2026
Who is this for?
This is a combination painkiller that contains two medicines — diclofenac sodium (which reduces pain, swelling, and inflammation) and paracetamol (which reduces pain and fever). Together, they work faster and stronger than either one alone.
Inhibits COX-1 and COX-2 enzymes, reducing prostaglandin synthesis to decrease pain, fever, and inflammation (diclofenac); while paracetamol inhibits COX-3 in the central nervous system and modulates endocannabinoid pathways, providing additional analgesic and antipyretic effects with minimal peripheral anti-inflammatory activity.
Available Over The Counter
Get this from any pharmacy or chemist — no prescription needed.
Explore this drug
Adults usually take 1 tablet two or three times a day, after food. Always take it with food or immediately after eating to protect your stomach. Swallow the tablet whole with a full glass of water — do not crush or chew it. Do not take more than 3 tablets in a day unless your doctor says so. Do not use it for more than 5-7 days without seeing a doctor.
If you miss a dose, take it as soon as you remember — but only if it is close to when you were supposed to take it. If it is almost time for your next dose, just skip the missed one and continue as normal. Never take two doses at once to make up for the one you missed.
Buy only from licensed pharmacies — brands like Dicloplus, Lofnac Plus, Alfemol, or Mazoka are common in Nigeria, but avoid buying unnamed or repackaged versions from roadside sellers. Do not use this drug for everyday headaches or body pain for weeks on end — long-term use can damage your stomach, liver, and kidneys. If pain continues after 5 days, see a doctor instead of increasing the dose yourself.
Avoid taking with alcohol — alcohol increases the risk of stomach bleeding and liver damage. Do not combine with other painkillers like ibuprofen or aspirin unless a doctor tells you to, as this increases the chance of stomach ulcer. If you are taking blood pressure drugs (like lisinopril or amlodipine), this drug can reduce their effectiveness — inform your doctor.
Check your specific combination
Is it safe to take Diclofenac with your other drugs?
This drug is not safe during pregnancy, especially in the last three months, and should be avoided while breastfeeding — always consult your doctor before using it if you are pregnant or nursing.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in your car or near windows. Keep it in the original pack and away from children. Do not use it if the tablets look discoloured or the pack is damaged.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Dispensing Diclofenac Sodium; Paracetamol?
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