Antiparasitic (Pediculicide/Scabicide)
Last reviewed June 2026
Who is this for?
Permethrin is an antiparasitic cream that kills lice and scabies mites by attacking their nervous system, causing them to become paralyzed and die.
Binds to voltage-gated sodium channels in the arthropod nervous system, causing prolonged depolarization, paralysis, and death of lice and mites. Acts as a neurotoxin specific to insects and arachnids due to their lower body temperature and different channel sensitivity compared to mammals.
Available Over The Counter
Get this from any pharmacy or chemist — no prescription needed.
Explore this drug
For scabies: Apply the 5% cream (like Everdestiny Permethrin Cream or Wings Permethrin Cream 5%) all over your body from the neck down to the soles of your feet. Massage it well into the skin, leave it on for 8 to 14 hours (usually overnight), then wash it off with warm water. One application is usually enough, but your doctor may ask you to repeat it after 7 days if the itching continues. For head lice: Apply the 1% cream or lotion to clean, damp hair, leave for 10 minutes, then rinse off.
Permethrin is not taken on a daily schedule — it is usually a one-time application. If you washed it off too early, reapply the cream and leave it on for the full recommended time.
Buy only from reputable pharmacies — brands like Everdestiny Permethrin Cream and Wings Permethrin Cream 5% are available in Nigeria. If you have scabies, wash all your clothes, bedsheets, and towels in hot water on the same day you apply the cream to prevent reinfection. Family members and close contacts should also be treated at the same time, even if they are not yet itching, to stop the spread.
Avoid using other medicated creams, lotions, or oils on the skin at the same time as permethrin, as they may reduce its effectiveness or increase irritation. Do not use shea butter, coconut oil, or other body oils immediately before applying — apply to clean, dry skin. There are no major food or alcohol interactions since it is applied on the skin and not swallowed.
Check your specific combination
Is it safe to take Permethrin with your other drugs?
Permethrin cream is generally considered safe during pregnancy and breastfeeding, but consult your doctor before using it to be sure.
Store in a cool, dry place away from direct sunlight and heat. Nigerian weather can be very hot, so avoid leaving it in cars or near windows. Keep out of the reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Dispensing Permethrin?
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