Antidepressant (Noradrenergic and Specific Serotonergic Antidepressant - NaSSA)
Last reviewed June 2026
Who is this for?
Mirtazapine is an antidepressant that works by increasing the levels of certain natural chemicals in the brain (serotonin and noradrenaline) that help improve your mood, appetite, and sleep.
Blocks presynaptic alpha-2 adrenergic receptors and H1 histamine receptors while antagonizing 5-HT2 and 5-HT3 serotonin receptors, resulting in increased noradrenaline and serotonin release and enhanced monoaminergic neurotransmission. This mechanism improves mood, reduces anxiety, and promotes sleep in depressive disorders.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
Adults usually start with one 15 mg tablet taken once daily at bedtime, since it can make you very sleepy. Your doctor may gradually increase the dose to 30 mg or 45 mg depending on how you respond. Swallow the tablet whole with water — it can be taken with or without food. Do not stop taking it suddenly without your doctor's advice, even if you feel better.
If you miss a dose, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed one and continue your normal schedule. Do not take a double dose to make up for it.
This is a prescription-only medicine — do not buy it from roadside vendors or open markets without a doctor's prescription. Do not stop taking it suddenly as it can cause withdrawal symptoms like dizziness, anxiety, and nausea; always let your doctor reduce the dose gradually. Do not share this medication with anyone else, even if they seem to have similar symptoms.
Avoid alcohol completely as it can dangerously increase drowsiness and slow your breathing. Do not take it with tramadol or other antidepressants like amitriptyline without your doctor's guidance, as the combination can cause a dangerous condition called serotonin syndrome (high fever, confusion, fast heartbeat). Sedatives and sleeping pills will make the drowsiness much worse.
Check your specific combination
Is it safe to take Mirtazapine with your other drugs?
Mirtazapine is not considered safe during pregnancy or breastfeeding — consult your doctor before using it if you are pregnant, planning to become pregnant, or nursing a baby.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in your car or near a window. Keep it in its original packaging and far out of reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Dispensing Mirtazapine?
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