Anticholinergic / Antiparkinsonian agent
Last reviewed June 2026
Who is this for?
Trihexyphenidyl (commonly called Benzhexol) is a drug that works by blocking a chemical called acetylcholine in the brain, which helps reduce muscle stiffness, trembling, and involuntary movements caused by certain conditions or medications.
Blocks muscarinic cholinergic receptors in the basal ganglia and central nervous system, reducing excessive cholinergic activity and restoring the balance between dopaminergic and cholinergic neurotransmission. This action alleviates tremor, rigidity, and bradykinesia associated with Parkinson's disease and drug-induced extrapyramidal side effects.
Prescription Required
You need a doctor's prescription to buy this drug.
Is Trihexyphenidyl safe to take with another drug?
Check with multiple drugs →Explore this drug
Adults usually start with 1 mg once daily, then the doctor gradually increases the dose to 5-15 mg daily, split into 3 doses taken with meals. Take it with food to reduce stomach upset. Swallow the tablet with water. Do not suddenly stop taking this drug without your doctor's advice — the dose should be reduced slowly. Common brands in Nigeria include Axzol, Chexol, and Benzhexol 5 mg Tablets.
If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed one and continue your normal schedule. Do not take a double dose to make up for it.
This is a prescription drug — do not buy it from roadside vendors or use someone else's prescription. It can cause drowsiness and blurred vision, so avoid driving okada, keke, or cars until you know how it affects you. Some people misuse this drug for its mind-altering effects — using it without a doctor's supervision is dangerous and can cause serious mental health problems.
Alcohol makes the drowsiness and dizziness from this drug much worse — avoid drinking while on it. Taking it with other drugs that cause drowsiness such as antihistamines (e.g. chlorpheniramine, promethazine) can make you very sleepy. Antacids like magnesium trisilicate may reduce how well the body absorbs this drug, so take them at different times.
Check your specific combination
Is it safe to take Trihexyphenidyl with your other drugs?
This drug is not considered safe during pregnancy and breastfeeding — consult your doctor before using it if you are pregnant, planning to become pregnant, or nursing a baby.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be hot, so avoid leaving it near windows or in your car. Keep the container tightly closed to protect from moisture and always keep it out of the reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
Tap a brand for packaging, NAFDAC details and authenticity check
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Dispensing Trihexyphenidyl Hydrochloride?
Clinical tools built for Nigerian pharmacists — launching soon.