JAK inhibitor (Immunosuppressant)
Last reviewed June 2026
Who is this for?
Tofacitinib (sold as Xeljanz) is a medicine that calms down your immune system by blocking certain enzymes called JAK enzymes that cause inflammation and joint damage in your body.
Inhibits Janus kinase (JAK) enzymes, blocking the JAK-STAT signaling pathway and reducing production of pro-inflammatory cytokines (interleukins and interferons) that drive joint inflammation and autoimmune responses in rheumatoid arthritis, psoriatic arthritis, and ulcerative colitis.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
Take one 5 mg tablet twice a day, morning and evening, with or without food. Swallow the tablet whole with water. Your doctor may adjust the dose depending on how your body responds.
If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed one and continue your normal schedule. Do not take two tablets at once to make up for the missed dose.
This is a strong prescription medicine — never buy it from roadside sellers or patent medicine stores without a doctor's prescription. Do not share this medication with anyone else, even if they have similar symptoms. You will need regular blood tests while taking this drug, so keep all your hospital appointments.
Avoid taking tofacitinib with other strong immune-suppressing drugs like methotrexate at high doses or azathioprine, as this increases the risk of serious infections. Some antibiotics and antifungals like ketoconazole can increase tofacitinib levels in your blood — tell your doctor about all medicines you are taking. Avoid alcohol as it can worsen liver-related side effects.
Check your specific combination
Is it safe to take Tofacitinib with your other drugs?
Tofacitinib is not safe during pregnancy or breastfeeding — women of childbearing age should use effective contraception during treatment and for at least 4 weeks after stopping the drug.
Store at room temperature, below 30°C. Keep it in a dry place away from direct sunlight and humidity — avoid storing in the bathroom or kitchen. Always keep it out of children's reach in a locked cupboard if possible.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Dispensing Tofacitinib?
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