How do you take Talazoparib (Talazoparib Tosylate)?

Take one 1 mg capsule by mouth once daily, with or without food. Swallow the capsule whole — do not open, chew, or dissolve it. Take it at roughly the same time each day. Your doctor will decide how long you need to stay on it and may adjust your dose based on how your body responds.

What are the side effects of Talazoparib (Talazoparib Tosylate)?

Feeling very tired or weak, low blood counts (which can cause easy bruising, bleeding, or frequent infections), nausea and vomiting, hair thinning or hair loss, loss of appetite

Who should not take Talazoparib (Talazoparib Tosylate)?

People who are allergic to talazoparib or any ingredient in the capsule, pregnant or breastfeeding women, and children should not take this drug. People with very low blood cell counts should discuss risks carefully with their doctor before starting.

Prescription

PARP inhibitor (cancer medicine)

Talazoparib

Last reviewed June 2026

Who is this for?

What is this drug?

Talazoparib (brand name Talzenna) is a cancer medicine that works by blocking a protein called PARP, which cancer cells need to repair their damaged DNA — without this repair, the cancer cells die.

What is it used for?

Breast cancer that has spread to other parts of the body (metastatic breast cancer)specifically in people who have a harmful BRCA gene change

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Cancer Treatment

How it works

Inhibits poly(ADP-ribose) polymerase (PARP) enzymes, preventing DNA repair in BRCA-mutant cancer cells and leading to accumulation of DNA damage and cell death. This synthetic lethality approach is particularly effective in tumours with BRCA1 or BRCA2 mutations that rely on PARP-mediated homologous recombination repair pathways.

Prescription Required

You need a doctor's prescription to buy this drug.

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What to watch out for

This is a highly specialized cancer drug — only take it if prescribed and supervised by an oncologist (cancer specialist). Do not buy from unverified sources or roadside sellers, as counterfeit cancer medicines are extremely dangerous. Regular blood tests are essential while on this medicine, so keep all your hospital appointments.

Common Side Effects

Feeling very tired or weak
low blood counts (which can cause easy bruising
bleeding
or frequent infections)
nausea and vomiting
hair thinning or hair loss
loss of appetite

Serious Side Effects

Severe drop in blood cells — watch for unusual bleeding
bruises that won't stop
very high fever
or extreme tiredness and breathlessness (this needs urgent hospital attention). In rare cases
it may increase the risk of developing a different type of blood cancer called MDS or AML.

Drug Interactions

Certain antibiotics and antifungals (like ketoconazole or itraconazole) can increase talazoparib levels dangerously in your body — always tell your doctor about any other medicine you are taking. Acid-reducing stomach drugs like omeprazole may also interact. Avoid alcohol as it can worsen side effects like tiredness and nausea.

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Pregnancy & Breastfeeding Warning

This drug is NOT safe during pregnancy or breastfeeding — it can cause serious harm to an unborn baby, and both men and women must use effective contraception during treatment and for some months after stopping.

Who Should NOT Take This

People who are allergic to talazoparib or any ingredient in the capsule
pregnant or breastfeeding women
and children should not take this drug. People with very low blood cell counts should discuss risks carefully with their doctor before starting.

How to Store

Store at room temperature, ideally below 30°C. Keep the capsules in their original container, away from direct sunlight and humidity. Store in a cool, dry place and always keep out of the reach of children.

For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.