Targeted cancer therapy (kinase inhibitor)
Last reviewed June 2026
Who is this for?
Sorafenib is a cancer medicine that works by blocking signals that help cancer cells grow and by cutting off the blood supply that feeds tumours, slowing down or stopping cancer growth.
Inhibits multiple receptor tyrosine kinases including VEGFR, PDGFR, RAF kinase, and FLT3, blocking tumor angiogenesis and cell proliferation pathways critical to cancer cell survival. Additionally suppresses mitogen-activated protein kinase (MAPK) signaling, further reducing tumor growth and metastatic potential.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
The usual adult dose is 2 tablets (400 mg) taken twice daily — that is 2 tablets in the morning and 2 tablets in the evening. Take the tablets on an empty stomach, at least 1 hour before or 2 hours after food. Swallow whole with a full glass of water. Your oncologist (cancer doctor) will tell you exactly how long to continue.
If you miss a dose and there are still several hours before your next dose, take it as soon as you remember. If it is almost time for your next dose, skip the missed one entirely — do not take a double dose to make up for it.
This is a very specialised cancer drug — only take it under the direct supervision of a cancer specialist (oncologist). Do not buy Nexavar from unregistered pharmacies or roadside sellers, as fake cancer drugs are extremely dangerous. Never share this medication with anyone else, even if they have a similar condition, and attend all your scheduled check-up appointments.
Rifampicin (commonly used for TB treatment in Nigeria) can reduce how well sorafenib works, so inform your doctor if you are on TB drugs. St. John's Wort herbal supplements can also reduce its effectiveness. Blood-thinning medicines like warfarin can increase the risk of dangerous bleeding when combined with sorafenib.
Check your specific combination
Is it safe to take Sorafenib with your other drugs?
Sorafenib is NOT safe during pregnancy as it can seriously harm the unborn baby, and breastfeeding mothers should not use it — both men and women should use reliable contraception during treatment and for at least 2 weeks after stopping.
Store in a cool, dry place below 25°C. Keep away from direct sunlight and humidity — do not store in the bathroom. In hot Nigerian weather, keep it in the coolest part of your room or a climate-controlled area. Always keep out of the reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Dispensing Sorafenib?
Clinical tools built for Nigerian pharmacists — launching soon.