How do you take Perindopril Arginine; Indapamide?

Take one tablet once a day, preferably in the morning before breakfast. Swallow the tablet whole with a glass of water. Do not crush or chew it. Your doctor will usually start you on one tablet of Coversyl Plus (5 mg/1.25 mg) daily.

What are the side effects of Perindopril Arginine; Indapamide?

Dry cough (very common with this type of drug), dizziness or feeling lightheaded especially when you stand up quickly, headache, feeling tired or weak, passing urine more often than usual because of the water pill component

Who should not take Perindopril Arginine; Indapamide?

People allergic to perindopril, indapamide, sulfonamide-related medicines, or any ACE inhibitor. People who have had swelling of the face or throat (angioedema) before. People with severe kidney or liver problems. Pregnant women or women planning to become pregnant. People with very low potassium levels. Diabetic patients already taking aliskiren (another blood pressure drug).

Prescription

ACE Inhibitor + Diuretic (combination blood pressure medicine)

Perindopril Arginine; Indapamide

Q: What is Perindopril Arginine; Indapamide used for?

High blood pressure (hypertension), reducing the risk of stroke and heart problems in people with high blood pressure

Last reviewed June 2026

Who is this for?

What is this drug?

This is a combination drug containing two blood pressure-lowering medicines — perindopril arginine (an ACE inhibitor) and indapamide (a water pill/diuretic). Perindopril relaxes your blood vessels while indapamide helps your body get rid of extra salt and water, and together they lower your blood pressure more effectively.

What is it used for?

High blood pressure (hypertension)reducing the risk of stroke and heart problems in people with high blood pressure

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High Blood Pressure

How it works

Inhibits angiotensin-converting enzyme (ACE), reducing formation of angiotensin II and causing vasodilation and decreased aldosterone secretion; concurrently blocks sodium reabsorption in the distal convoluted tubule through thiazide-like diuretic action, promoting sodium and water excretion to reduce blood volume and arterial pressure.

Prescription Required

You need a doctor's prescription to buy this drug.

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What to watch out for

Always buy this drug from a licensed pharmacy — do not buy from roadside sellers or open markets, as fake blood pressure drugs are common in Nigeria. Do not stop taking this medicine suddenly because your blood pressure feels normal — high blood pressure often has no symptoms but still damages your body. Do not share this prescription medicine with anyone else, even if they also have high blood pressure.

Common Side Effects

Dry cough (very common with this type of drug)
dizziness or feeling lightheaded especially when you stand up quickly
headache
feeling tired or weak
passing urine more often than usual because of the water pill component

Serious Side Effects

Swelling of the face
lips
tongue or throat that makes it hard to breathe — go to the hospital immediately. Severe dizziness or fainting
which could mean your blood pressure has dropped too low. Signs of kidney problems like passing very little or no urine — see a doctor right away.

Drug Interactions

Avoid taking potassium supplements or potassium-rich salt substitutes without your doctor's advice, as this drug can affect potassium levels. NSAIDs like ibuprofen (commonly sold as Brufen in Nigeria) can reduce the effect of this drug and harm your kidneys if used together regularly. Avoid drinking alcohol as it can increase the blood pressure-lowering effect and make you feel very dizzy or faint.

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Pregnancy & Breastfeeding Warning

This drug is NOT safe during pregnancy — it can seriously harm or even kill your unborn baby, especially in the second and third trimesters. It is also not recommended during breastfeeding. Tell your doctor immediately if you become pregnant while taking it.

Who Should NOT Take This

People allergic to perindopril
indapamide
sulfonamide-related medicines
or any ACE inhibitor. People who have had swelling of the face or throat (angioedema) before. People with severe kidney or liver problems. Pregnant women or women planning to become pregnant. People with very low potassium levels. Diabetic patients already taking aliskiren (another blood pressure drug).

How to Store

Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so do not leave it in your car or near a window. Keep the tablets in their original container and keep them far from the reach of children.

For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.