Cold and Flu Combination (Painkiller, Nasal Decongestant, Cough Suppressant)
Last reviewed June 2026
Who is this for?
This is a combination medicine containing three active ingredients — paracetamol (a painkiller and fever reducer), phenylephrine (which unblocks your stuffy nose), and dextromethorphan (which calms down coughing). Together, they relieve multiple cold and flu symptoms at once.
Inhibits COX-1 and COX-2 enzymes, reducing prostaglandin synthesis to decrease fever, pain, and headache; activates alpha-1 adrenergic receptors causing vasoconstriction of nasal blood vessels to relieve congestion; suppresses cough by inhibiting the cough centre in the medulla oblongata.
Available Over The Counter
Get this from any pharmacy or chemist — no prescription needed.
Explore this drug
For adults, take 1 capsule every 4 to 6 hours as needed, with or without food. Do not take more than 4 capsules in 24 hours. Swallow with a full glass of water. A common brand in Nigeria is Zedex Cold 325 mg Capsule.
Since this medicine is taken only when you have symptoms, there is no strict schedule. If you forget a dose, just take it when you remember. But do not take two doses at once or exceed 4 capsules in a day.
Do not combine this with other cold medicines or paracetamol products — many Nigerian cold remedies already contain paracetamol and doubling up can seriously damage your liver. Buy only from a registered pharmacy, not roadside sellers, to avoid fake or expired products. Stop using and see a doctor if your symptoms do not improve after 5 days or get worse.
Do not take with alcohol as it increases the risk of liver damage from paracetamol and can make drowsiness much worse. Avoid taking alongside other paracetamol-containing medicines (like Boska or Procold) to prevent accidental overdose. Do not combine with MAO inhibitor medications or other cough suppressants without a doctor's advice.
Check your specific combination
Is it safe to take Paracetamol; with your other drugs?
If you are pregnant or breastfeeding, consult your doctor or pharmacist before taking this medicine — some of the ingredients may not be safe for your baby.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in your car or near a window. Keep away from moisture and always store out of the reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Dispensing Paracetamol; Phenylephrine; Dextromethorphan?
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