Cough and Cold Combination (Painkiller, Antihistamine, Expectorant)
Last reviewed June 2026
Who is this for?
This is a combination syrup that contains four active ingredients working together — paracetamol reduces fever and pain, oxomemazine calms cough by acting on the brain's cough center, guaifenesin loosens thick mucus in your chest so you can cough it out easily, and sodium benzoate also helps thin out mucus.
Inhibits COX-1 and COX-2 enzymes reducing prostaglandin synthesis to decrease fever and pain; blocks H1 histamine receptors to suppress allergic responses and cough; and increases respiratory tract fluid secretion to facilitate mucus expectoration while sodium benzoate acts as a mild antimicrobial preservative.
Available Over The Counter
Get this from any pharmacy or chemist — no prescription needed.
Explore this drug
For adults, take 1-2 tablespoons (15-30ml) of the syrup 2-3 times a day. You can take it with or without food. Shake the bottle well before each use. Do not exceed the recommended dose because of the paracetamol content. Known in Nigeria as Oplex Syrup.
If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, just skip the missed one and continue as normal. Do not double up to make up for the missed dose.
This medicine makes you very drowsy — do not drive, ride okada, or operate heavy machines after taking it. Buy only from reputable pharmacies and check the NAFDAC number on the Oplex Syrup bottle to avoid fake products. Do not use this syrup for more than 5-7 days without seeing a doctor — if your cough persists, it could be something more serious.
Do not drink alcohol while taking this syrup — both the oxomemazine and paracetamol can cause serious problems with alcohol, including liver damage and extreme drowsiness. Avoid taking extra paracetamol tablets (like Panadol or Emzor Paracetamol) alongside this syrup since it already contains paracetamol and you may overdose. Be careful with sleeping pills or antihistamines like Piriton as the drowsiness can become dangerously strong.
Check your specific combination
Is it safe to take Paracetamol; with your other drugs?
Do not use this medicine during pregnancy or while breastfeeding unless your doctor specifically says it is okay, as some of the ingredients can affect the baby.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid storing near windows or in your car. Keep the bottle tightly closed after use and keep it far away from children's reach.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
Tap a brand for packaging, NAFDAC details and authenticity check
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.