Anti-emetic (5-HT3 receptor antagonist)
Last reviewed June 2026
Who is this for?
Palonosetron is an anti-nausea injection that works by blocking a chemical called serotonin in your body, which is the main trigger for vomiting, especially after chemotherapy (cancer treatment drugs).
Binds selectively to 5-HT3 receptors on vagal afferent nerves and chemoreceptor trigger zone neurons, blocking serotonin-mediated activation of the vomiting centre and preventing nausea and vomiting associated with chemotherapy and postoperative settings.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
This is not a tablet — it is given as an injection into your vein (IV) by a doctor or nurse in a hospital. For chemotherapy-related nausea, a single dose of 0.25 mg is given about 30 minutes before your chemotherapy session. For post-surgery nausea, 0.075 mg is given just before the surgery starts. You do not take this drug at home by yourself.
Since this drug is given by a doctor or nurse in a hospital setting before a specific procedure, missing a dose on your own is unlikely. If for any reason it was not given before your treatment, inform your doctor immediately.
This injection should only be given in a hospital or clinic by a trained healthcare professional — never attempt to self-administer. Make sure the injection is sourced from a reputable pharmacy or hospital, not from unregistered sellers. If you experience chest pain or an unusual heartbeat after receiving the injection, report to the medical team immediately.
Be careful if you are taking antidepressants like SSRIs (e.g., fluoxetine or sertraline) as combining them can cause a dangerous condition called serotonin syndrome. Drugs that affect your heart rhythm (like some antibiotics or heart medications) may interact badly. Always tell your doctor every drug you are currently taking, including herbal remedies.
Check your specific combination
Is it safe to take Palonosetron with your other drugs?
There is not enough safety data for pregnant or breastfeeding women — consult your doctor before receiving this injection if you are pregnant, planning to become pregnant, or breastfeeding.
Store at room temperature, but avoid extreme heat and direct sunlight — do not leave it in a hot car or near a window. Keep it in its original packaging until ready for use. Keep away from children. Hospital and pharmacy staff should ensure proper cold chain where required.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
Tap a brand for packaging, NAFDAC details and authenticity check
Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Dispensing Palonosetron Hydrochloride?
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