How do you take Olmesartan Medoxomil; Hydrochlorothiazide; Amlodipine?

Take one tablet once a day, at the same time each day. You can take it with or without food. Swallow whole with a glass of water — do not crush or chew. Your doctor will decide the right strength for you based on how well your blood pressure is controlled.

What are the side effects of Olmesartan Medoxomil; Hydrochlorothiazide; Amlodipine?

Dizziness or feeling lightheaded (especially when you stand up quickly), swelling in the ankles or feet, feeling tired or weak, passing urine more often than usual, mild headache

Who should not take Olmesartan Medoxomil; Hydrochlorothiazide; Amlodipine?

People allergic to any of the three ingredients (olmesartan, hydrochlorothiazide, or amlodipine) or to sulfonamide-related medicines. People with severe liver disease, severe kidney problems, or who cannot pass urine. People with very low blood pressure. Diabetic patients taking a medicine called aliskiren. Pregnant women.

Prescription

Antihypertensive (combination blood pressure medicine)

Olmesartan Medoxomil; Hydrochlorothiazide; Amlodipine

Q: What is Olmesartan Medoxomil; Hydrochlorothiazide; Amlodipine used for?

High blood pressure (hypertension), especially when one or two medicines alone are not enough to control it

Last reviewed June 2026

Who is this for?

What is this drug?

This is a combination tablet containing three medicines — Olmesartan, Hydrochlorothiazide, and Amlodipine — that work together to lower high blood pressure. Olmesartan relaxes blood vessels, Hydrochlorothiazide helps your kidneys flush out extra water and salt, and Amlodipine relaxes the walls of your blood vessels so blood flows more easily.

What is it used for?

High blood pressure (hypertension)especially when one or two medicines alone are not enough to control it

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High Blood Pressure

How it works

Blocks angiotensin II AT1 receptors (olmesartan medoxomil), inhibits sodium reabsorption in the distal convoluted tubule via thiazide diuretic action (hydrochlorothiazide), and blocks L-type calcium channels in vascular smooth muscle (amlodipine), thereby reducing peripheral vascular resistance and blood pressure through complementary mechanisms.

Prescription Required

You need a doctor's prescription to buy this drug.

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What to watch out for

Do not stop taking this medicine on your own because you feel fine — high blood pressure often has no symptoms but can cause stroke or heart attack if untreated. Always buy from a licensed pharmacy and check the expiry date, not from roadside vendors or market sellers. Do not share this medicine with anyone else, even if they also have high blood pressure — the combination and dose may not be right for them.

Common Side Effects

Dizziness or feeling lightheaded (especially when you stand up quickly)
swelling in the ankles or feet
feeling tired or weak
passing urine more often than usual
mild headache

Serious Side Effects

Severe dizziness or fainting — this could mean your blood pressure has dropped too low. Swelling of the face
lips
tongue or throat with difficulty breathing (allergic reaction) — go to the hospital immediately. Signs of kidney problems like very little urine output or swollen legs.

Drug Interactions

Avoid taking with other blood pressure medicines or potassium supplements without your doctor's knowledge, as it can cause your blood pressure or potassium levels to go dangerously low or high. NSAIDs (painkillers like ibuprofen and diclofenac) can reduce how well this medicine works and may harm your kidneys. Limit alcohol as it can worsen dizziness and further lower your blood pressure.

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Pregnancy & Breastfeeding Warning

This medicine is NOT safe during pregnancy — it can seriously harm or even kill your unborn baby, especially from the second trimester. If you are pregnant, planning to become pregnant, or breastfeeding, tell your doctor immediately.

Who Should NOT Take This

People allergic to any of the three ingredients (olmesartan
hydrochlorothiazide
or amlodipine) or to sulfonamide-related medicines. People with severe liver disease
severe kidney problems
or who cannot pass urine. People with very low blood pressure. Diabetic patients taking a medicine called aliskiren. Pregnant women.

How to Store

Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid storing near windows or in your car. Keep the tablets in their original pack and far away from children's reach.

For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.