Anti-inflammatory painkiller with stomach protector (NSAID + Proton Pump Inhibitor)
Last reviewed June 2026
Who is this for?
This is a combination drug containing naproxen (a painkiller and anti-inflammatory medicine) and esomeprazole (a stomach-protecting medicine that reduces acid). The esomeprazole is added to help protect your stomach from the irritation and ulcers that naproxen can cause.
Inhibits COX-1 and COX-2 enzymes to reduce prostaglandin-mediated pain and inflammation, while esomeprazole blocks H+/K+-ATPase proton pumps in gastric parietal cells to suppress gastric acid secretion and protect against NSAID-induced ulceration.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
The usual dose is one tablet twice daily — one in the morning and one in the evening. Swallow the tablet whole with water; do not crush, chew, or break it. It is best taken at least 30 minutes before a meal.
If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed one and continue your normal schedule. Do not take two tablets at once to make up for the missed dose.
Only buy from licensed pharmacies — this is a prescription medicine, so avoid buying from roadside sellers or open markets where you cannot be sure of the quality. Do not use this drug for everyday body pain or headache — it is meant for specific conditions and long-term use should be monitored by a doctor. If you notice dark-coloured stool or stomach pain that gets worse, stop the drug and see your doctor immediately.
Avoid taking this with other painkillers like ibuprofen or diclofenac as this increases the risk of stomach bleeding. If you are taking blood-thinning medicines like warfarin or aspirin, talk to your doctor first as the combination can cause dangerous bleeding. Avoid alcohol while using this drug as it greatly increases your risk of stomach problems.
Check your specific combination
Is it safe to take Naproxen; with your other drugs?
This medicine is not safe during pregnancy, especially in the last three months, and should be avoided during breastfeeding — always consult your doctor before use.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in your car or near windows. Keep it in its original container and far away from children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.