Antibacterial and Antifungal combination
Last reviewed June 2026
Who is this for?
This is a combination vaginal cream or pessary (insert) that contains two medicines — metronidazole (which kills bacteria) and miconazole (which kills fungus/yeast). Together they treat mixed vaginal infections caused by both bacteria and fungus at the same time.
Inhibits bacterial DNA synthesis by intercalating into DNA strands and disrupting nucleic acid replication in anaerobes, while disrupting fungal cell membrane integrity by inhibiting ergosterol synthesis, effectively eliminating both bacterial and fungal pathogens responsible for mixed vaginal infections.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
For adults, insert one pessary or one applicator-full of cream deep into the vagina, usually once at bedtime for 7 to 14 days depending on your doctor's instruction. Wash your hands before and after use. It is best to use it at night so the medicine stays in place while you sleep. In Nigeria, you may find it sold as Drez V.
If you forget to insert a dose at bedtime, use it as soon as you remember. If it is almost time for the next dose, skip the missed one and continue your regular schedule. Do not use double the amount to make up for a missed dose.
Complete the full course of treatment even if your symptoms improve after a few days — stopping early can cause the infection to come back stronger. Do not buy from roadside sellers or unregistered patent medicine stores as storage conditions matter for this product. Avoid sexual intercourse during treatment, and do not share this medication with anyone else even if they have similar symptoms.
Avoid drinking alcohol while using this medication — metronidazole and alcohol together can cause serious nausea, vomiting, and stomach cramps. If you are taking warfarin (a blood thinner), tell your doctor as metronidazole can increase the risk of bleeding. Also inform your doctor if you use latex condoms or diaphragms, as the cream base can weaken them and reduce their effectiveness.
Check your specific combination
Is it safe to take Metronidazole; with your other drugs?
Do not use this medication during pregnancy (especially the first three months) or while breastfeeding unless your doctor specifically tells you it is safe — always consult your doctor first.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in places like your car or near a window. Keep it below 25°C if possible and always keep it out of the reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.