Topical corticosteroid and antibiotic combination
Last reviewed June 2026
Who is this for?
This is a combination medicine containing a steroid (methylprednisolone acetate) that reduces swelling and inflammation, and an antibiotic (neomycin sulfate) that fights bacterial infections on the skin. It is typically used as a topical preparation like a lotion or cream applied directly to the skin.
Binds to glucocorticoid receptors in the cytoplasm, translocating to the nucleus to suppress inflammatory gene expression and reduce cytokine production, while neomycin inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, effectively treating concurrent bacterial infection.
Prescription Required
You need a doctor's prescription to buy this drug.
Is Methylprednisolone safe to take with another drug?
Check with multiple drugs →Explore this drug
Apply a thin layer of the lotion (such as Neo Presol Lotion) to the affected area of skin 1 to 3 times daily, or as directed by your doctor. Gently rub it in. Do not cover the area with tight bandages unless your doctor tells you to. Wash your hands after applying unless you are treating your hands.
If you forget to apply it, use it as soon as you remember. If it is almost time for your next application, skip the missed one and continue as normal. Do not apply double the amount to make up for the missed dose.
Important for antibiotics
Always complete the full course even if you feel better. Stopping early can cause the infection to return and become drug-resistant.
Do not use this medicine for longer than your doctor recommends — using steroid creams for too long can damage your skin permanently. Buy only from licensed pharmacies, not roadside sellers, to make sure you are getting the genuine Neo Presol Lotion. Do not share this medicine with others even if they have similar skin problems, as their condition may be different.
Avoid using other steroid creams or lotions on the same area at the same time, as this can increase side effects. If you are using other skin products like antifungal creams, ask your doctor or pharmacist before combining them. Let your doctor know if you are taking any other medicines, especially steroids by mouth or injection.
Check your specific combination
Is it safe to take Methylprednisolone with your other drugs?
Do not use this medicine during pregnancy or breastfeeding unless your doctor specifically prescribes it, as the steroid component may pose risks to the baby.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in your car or near windows. Keep the container tightly closed and out of reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.