Cholesterol-lowering agent (PCSK9 inhibitor — siRNA type)
Last reviewed June 2026
Who is this for?
Inclisiran (sold as Sybrava in Nigeria) is an injectable medicine that lowers bad cholesterol (LDL) in your blood by helping your liver clear it out more effectively. It works by silencing a specific gene that normally stops your liver from removing cholesterol.
Inhibits PCSK9 (proprotein convertase subtilisin/kexin type 9) by silencing its mRNA through RNA interference, thereby increasing hepatic LDL receptor expression and enhancing clearance of LDL cholesterol from the bloodstream.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
This is NOT a medicine you take at home — it is an injection given by a doctor or nurse under the skin (usually in the belly, upper arm, or thigh). You get the first injection, then another one after 3 months, and after that you only need one injection every 6 months. You do not need to worry about food timing since it is an injection.
If you miss your scheduled injection appointment, contact your doctor as soon as possible to reschedule. If it has been less than 3 months since your missed dose, get the injection and continue with your original schedule. If it has been more than 3 months, your doctor will restart the dosing schedule.
This injection must be given by a trained healthcare professional — do not attempt to buy or administer it yourself from unauthorized sources. Make sure you keep your follow-up appointments every 6 months so you do not miss a dose. Only get this medicine from a licensed hospital or pharmacy — avoid unregistered sellers, as fake or improperly stored injections can be dangerous.
Inclisiran does not have many known drug interactions, but always tell your doctor about all medicines you are taking, including herbal remedies and supplements. If you are already taking other cholesterol-lowering medicines like statins (e.g., atorvastatin, rosuvastatin), your doctor will adjust your treatment plan. There is no known interaction with alcohol, but reducing alcohol intake is generally advised when managing high cholesterol.
Check your specific combination
Is it safe to take Inclisiran with your other drugs?
Inclisiran should not be used during pregnancy or breastfeeding — consult your doctor immediately if you are pregnant, planning to become pregnant, or breastfeeding.
Sybrava should be stored in a refrigerator (2°C to 8°C). If no fridge is available, it can be kept at room temperature below 30°C but must be used within 24 hours. Do not freeze it. Keep it away from direct sunlight and heat — this is important in Nigeria's hot climate. Keep out of reach of children. Your doctor or hospital will usually handle storage.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Dispensing Inclisiran?
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