Corticosteroid and Antibiotic combination (topical)
Last reviewed June 2026
Who is this for?
This is a combination cream containing hydrocortisone (a steroid that reduces swelling, redness, and itching) and gentamicin (an antibiotic that kills bacteria). It works by treating skin infections while also calming inflammation at the same time.
Binds to glucocorticoid receptors to suppress inflammatory cytokine production and immune cell infiltration, while gentamicin inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, providing dual anti-inflammatory and antimicrobial action against infected skin lesions.
Prescription Required
You need a doctor's prescription to buy this drug.
Is Hydrocortisone; safe to take with another drug?
Check with multiple drugs →Explore this drug
Apply a thin layer of the cream to the affected skin area 2 to 3 times daily. Gently rub it in and wash your hands after applying unless you are treating your hands. Do not cover the area with a tight bandage unless your doctor tells you to. Usually used for 7 to 14 days — do not use for longer without a doctor's advice.
If you forget to apply the cream, apply it as soon as you remember. If it is almost time for your next application, skip the missed one and continue as normal. Do not apply double the amount to make up for a missed dose.
Important for antibiotics
Always complete the full course even if you feel better. Stopping early can cause the infection to return and become drug-resistant.
Do not use this cream for longer than your doctor recommended — using steroid creams for too long can thin your skin and cause permanent damage. Buy only from reputable pharmacies and look for known brands like Drugent-HC Cream, not unbranded products from roadside sellers. Do not share this cream with others even if they have similar skin problems, as the wrong use of antibiotics can cause resistance.
Avoid using other steroid creams or medicated skin products on the same area at the same time unless your doctor says so. If you are using other antibiotic creams or ointments, tell your doctor to avoid overloading your skin. Oral steroids like prednisolone taken together with this cream may increase steroid side effects.
Check your specific combination
Is it safe to take Hydrocortisone; with your other drugs?
Do not use this cream during pregnancy or breastfeeding without consulting your doctor first, as the steroid and antibiotic components may pose risks to the baby.
Store below 25°C in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in your car or near windows. Keep the tube tightly closed and out of reach of children. Do not use if the cream has changed colour or smells off.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.