How do you take Fluticasone Propionate; Salmeterol (Salmeterol Xinafoate)?

For adults, the usual dose is 2 puffs twice daily — one in the morning and one in the evening, about 12 hours apart. Your doctor will choose the right strength (125 mcg or 250 mcg fluticasone) based on how severe your asthma is. After each use, rinse your mouth with water and spit it out to prevent mouth infections. This inhaler is for daily prevention — it is not a rescue inhaler for sudden attacks.

What are the side effects of Fluticasone Propionate; Salmeterol (Salmeterol Xinafoate)?

Sore throat or hoarse voice, headache, mouth infection that looks like white patches (called oral thrush), muscle cramps, mild trembling or shaking of hands

Who should not take Fluticasone Propionate; Salmeterol (Salmeterol Xinafoate)?

People who are allergic to fluticasone, salmeterol, or any ingredient in the inhaler. Do not use this inhaler alone to treat a sudden asthma attack — you need a separate reliever inhaler (like salbutamol/Ventolin) for that. People with untreated fungal, bacterial, or viral infections should inform their doctor before use.

Prescription

Combination corticosteroid and long-acting bronchodilator (asthma preventer)

Fluticasone Propionate; Salmeterol

Q: What is Fluticasone Propionate; Salmeterol (Salmeterol Xinafoate) used for?

Asthma, chronic obstructive pulmonary disease (COPD, also called long-term breathing difficulty), wheezing, shortness of breath

Last reviewed June 2026

Who is this for?

What is this drug?

This is a combination inhaler that contains two medicines — fluticasone (which reduces swelling and inflammation in your airways) and salmeterol (which relaxes the muscles around your airways to help you breathe easier). Together, they work to keep your airways open and calm.

What is it used for?

Asthmachronic obstructive pulmonary disease (COPDalso called long-term breathing difficulty)wheezingshortness of breath

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How it works

Activates beta-2 adrenergic receptors to promote bronchial smooth muscle relaxation and airway dilation, while fluticasone propionate binds to glucocorticoid receptors in the cytoplasm to suppress inflammatory gene transcription, reducing airway inflammation and mucus production.

Prescription Required

You need a doctor's prescription to buy this drug.

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What to watch out for

Always buy your inhaler from a reputable pharmacy — do not buy from roadside sellers or open markets, as storage conditions matter a lot for inhalers. This is a preventer inhaler, not a rescue inhaler — always carry your reliever inhaler (e.g. Ventolin) separately for emergencies. Do not stop using it suddenly even if you feel better; let your doctor guide you on when and how to reduce the dose.

Common Side Effects

Sore throat or hoarse voice
headache
mouth infection that looks like white patches (called oral thrush)
muscle cramps
mild trembling or shaking of hands

Serious Side Effects

Sudden worsening of breathing difficulty or wheezing right after using the inhaler — seek emergency help immediately. Fast or irregular heartbeat
chest pain
or signs of severe allergic reaction like swelling of face
lips or tongue. If your asthma seems to be getting worse despite using this inhaler regularly
see your doctor urgently.

Drug Interactions

Avoid using with ketoconazole or itraconazole (common antifungal drugs in Nigeria) as they can increase side effects of fluticasone. Be careful with certain heart or blood pressure medicines like beta-blockers (e.g. propranolol) as they can reduce the effect of salmeterol. Tell your doctor if you are taking any HIV medicines like ritonavir.

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Pregnancy & Breastfeeding Warning

Do not use during pregnancy or breastfeeding without consulting your doctor — use only if the benefit clearly outweighs the risk.

Who Should NOT Take This

People who are allergic to fluticasone
salmeterol
or any ingredient in the inhaler. Do not use this inhaler alone to treat a sudden asthma attack — you need a separate reliever inhaler (like salbutamol/Ventolin) for that. People with untreated fungal
bacterial
or viral infections should inform their doctor before use.

How to Store

Store at room temperature, away from direct sunlight and heat. In Nigeria's hot climate, do not leave it in a car or near a window. Keep it dry and away from humidity. Do not puncture or burn the canister. Always keep out of reach of children.

For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.