Hormone (Estrogen)
Last reviewed June 2026
Who is this for?
Estradiol is a form of estrogen, which is a natural female hormone. It works by replacing the estrogen your body is no longer making enough of, helping to balance your hormone levels.
Binds to estrogen receptors (α and β) in target tissues, activating genomic and non-genomic signaling pathways that restore estrogen-dependent gene expression, alleviate vasomotor symptoms, and promote bone mineralization to prevent osteoporosis.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
Usually taken as one tablet daily, with or without food. Your doctor will decide the exact dose — it typically ranges from 0.5 mg to 2 mg once a day. Try to take it at the same time each day. Swallow the tablet whole with water. In Nigeria, you may find it sold as Tryal Tablets.
If you miss a dose, take it as soon as you remember. But if it is almost time for your next dose, skip the missed one and continue your normal schedule. Do not take two tablets at once to make up for the one you missed.
Only use estradiol if a doctor has prescribed it for you — do not self-medicate or buy from roadside sellers. Go for regular check-ups and breast examinations while using this medicine, as your doctor needs to monitor you. Do not share this medication with others, even if they have similar symptoms.
St. John's Wort (a herbal supplement) can reduce how well estradiol works. Some anti-seizure drugs like carbamazepine and phenytoin can also make it less effective. Grapefruit juice may increase the amount of estradiol in your blood, so limit it.
Check your specific combination
Is it safe to take Estradiol with your other drugs?
Estradiol is NOT safe during pregnancy or breastfeeding — it can harm your baby. If you suspect you are pregnant, stop taking it and see your doctor immediately.
Store in a cool, dry place away from direct sunlight and heat — this is especially important in hot Nigerian weather. Keep the tablets in their original pack and far away from children. Do not store in the bathroom where humidity is high.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.