Antiretroviral (Integrase Strand Transfer Inhibitor - INSTI)
Last reviewed June 2026
Who is this for?
Dolutegravir is an antiretroviral (anti-HIV) drug that works by blocking an enzyme called integrase, which the HIV virus needs to multiply inside your body. By blocking this enzyme, the drug helps reduce the amount of HIV in your blood and keeps your immune system stronger.
Inhibits HIV integrase enzyme, preventing the integration of viral DNA into the host cell's chromosomal DNA and blocking viral replication. This action stops the establishment of persistent HIV infection and reduces viral load in treated patients.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
For most adults, take one 50 mg tablet once a day, with or without food. If you are also taking certain other medicines like efavirenz, rifampicin (used for TB treatment), or some other drugs, your doctor may ask you to take it twice a day — one tablet in the morning and one in the evening. Always follow your doctor's instructions exactly.
If you remember the same day, take it as soon as you can. If it is almost time for your next dose, skip the missed one and continue your normal schedule. Never take two tablets at once to make up for a missed dose. Try to take your medicine at the same time every day to help you remember.
Always get your HIV medicines from a registered pharmacy or your treatment centre — do not buy from roadside sellers or unverified sources, as fake antiretrovirals are dangerous. Never stop taking this medicine or skip doses because you feel fine — HIV drugs must be taken every single day without fail to keep the virus under control. Do not share your HIV medication with anyone else, even if they also have HIV, as dosing may differ.
Rifampicin (commonly used for TB treatment in Nigeria) — if you are being treated for TB, tell your doctor because your Dolutegravir dose may need to be increased to twice daily. Antacids, calcium supplements, and iron tablets — do not take these at the same time as Dolutegravir; take them at least 2 hours before or 6 hours after your dose, as they reduce how well the drug works. Alcohol should be limited as it can worsen side effects like liver problems and make it harder for you to remember your doses consistently.
Check your specific combination
Is it safe to take Dolutegravir with your other drugs?
Dolutegravir is now considered safe for use during pregnancy and breastfeeding in Nigeria and is widely recommended, but always inform your doctor if you are pregnant, planning to become pregnant, or breastfeeding so they can monitor you properly.
Store at room temperature, away from direct sunlight and heat — Nigeria can be very hot, so do not leave it in a car or near a window. Keep it in a cool, dry place away from moisture and humidity. Always keep it in the original container with the lid tightly closed, and store well out of the reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
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