Question 1

What is Clozapine used for?

Accepted Answer

Treatment-resistant schizophrenia (severe mental illness where the person hears voices, sees things that are not there, or has confused thinking that other medicines have failed to control), reducing the risk of suicidal behavior in people with schizophrenia

Question 2

How do you take Clozapine?

Accepted Answer

Your doctor will start you on a very low dose — usually half of a 25 mg tablet (12.5 mg) once or twice a day — and slowly increase it over several weeks. The usual effective dose is between 200 mg and 450 mg per day, divided into 2 or 3 doses. You can take it with or without food. Never increase or decrease the dose on your own — always follow your doctor's instructions exactly.

Question 3

What are the side effects of Clozapine?

Accepted Answer

Feeling very sleepy or drowsy (especially when starting), drooling or excess saliva especially at night, dizziness when standing up quickly, weight gain and increased appetite, constipation

Question 4

Who should not take Clozapine?

Accepted Answer

People who are allergic to clozapine, people with a history of low white blood cell count (agranulocytosis), people with uncontrolled epilepsy, people with severe heart disease or active liver problems, people who cannot commit to the required regular blood tests, and anyone with a bowel obstruction or paralytic ileus.

Question 5

Is Clozapine safe during pregnancy?

Accepted Answer

Clozapine is not considered safe during pregnancy or breastfeeding — it can affect the baby, so consult your doctor immediately if you are pregnant, planning to become pregnant, or breastfeeding.

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