Antifungal and Antibiotic combination (topical)
Last reviewed June 2026
Who is this for?
This is a combination cream that contains two active ingredients — Clotrimazole (an antifungal) and Gentamicin (an antibiotic). Clotrimazole kills fungus and yeast on the skin, while Gentamicin fights bacteria, so together they treat skin infections that involve both fungus and bacteria.
Inhibits fungal ergosterol synthesis by binding to lanosterol 14α-demethylase (CYP51), while gentamicin disrupts bacterial protein synthesis by binding to the 30S ribosomal subunit, together providing broad-spectrum coverage against polymicrobial skin infections.
Prescription Required
You need a doctor's prescription to buy this drug.
Explore this drug
Apply a thin layer of the cream to the affected area of skin 2 to 3 times daily. Gently rub it in until it disappears. Wash and dry the area before applying. Continue using it for the full duration your doctor or pharmacist recommends, even if the skin starts looking better — stopping too early can bring the infection back.
If you forget to apply the cream, apply it as soon as you remember. If it is almost time for your next application, just skip the missed one and continue as normal. Do not apply double the amount to make up for it.
Important for antibiotics
Always complete the full course even if you feel better. Stopping early can cause the infection to return and become drug-resistant.
Complete the full course of treatment even if your skin looks better — stopping early can cause the infection to return or become resistant. Buy only from reputable pharmacies and not from roadside sellers, as counterfeit creams are common in Nigeria. Do not share your cream with others, as skin infections vary and what works for you may not be right for someone else.
Avoid applying other creams, lotions, or ointments on the same area at the same time unless your doctor says it is okay. Do not mix with steroid creams (like those containing betamethasone or hydrocortisone) unless specifically prescribed together, as this can mask worsening infections.
Check your specific combination
Is it safe to take Clotrimazole; with your other drugs?
If you are pregnant or breastfeeding, consult your doctor before using this cream — it should only be used if your doctor considers it necessary.
Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid leaving it in cars or near windows. Keep the tube tightly closed after use. Always keep out of the reach of children.
For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.
Names this drug is sold under — especially in Nigerian and West African pharmacies
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Counterfeit Drug Warning
Fake drugs are a serious problem in Nigeria. Always buy from a registered pharmacy. If the packaging looks different from what is described above, do not use it.
Dispensing Clotrimazole; Gentamicin?
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