How do you take Amlodipine (Amlodipine Besilate); Perindopril?

Take one tablet once daily, preferably in the morning before food. Swallow it whole with a glass of water. Your doctor will decide which strength is right for you — common strengths in Nigeria include Coveram 5mg/5mg, 5mg/10mg, 10mg/5mg, and 10mg/10mg. Do not stop taking it even if you feel fine, as high blood pressure often has no symptoms.

What are the side effects of Amlodipine (Amlodipine Besilate); Perindopril?

Swelling of the ankles or feet, feeling dizzy or lightheaded, headache, dry cough (this is common with Perindopril and usually not dangerous), feeling tired or weak

Who should not take Amlodipine (Amlodipine Besilate); Perindopril?

People allergic to Amlodipine, Perindopril, or any ACE inhibitor. People who have ever had swelling of the face or throat (angioedema) from a blood pressure medicine. People with very low blood pressure, severe kidney disease, or narrowing of the heart valve (aortic stenosis). Diabetic patients already taking Aliskiren should avoid this drug.

Prescription

Antihypertensive (Calcium Channel Blocker + ACE Inhibitor combination)

Amlodipine; Perindopril

Q: What is Amlodipine (Amlodipine Besilate); Perindopril used for?

High blood pressure (hypertension), prevention of heart attack and stroke, chest pain from heart problems (angina)

Last reviewed June 2026

Who is this for?

What is this drug?

This is a combination medicine containing two blood pressure-lowering drugs — Amlodipine (which relaxes your blood vessels) and Perindopril (which stops your body from producing a chemical that tightens blood vessels). Together, they work to bring your blood pressure down more effectively than either drug alone.

What is it used for?

High blood pressure (hypertension)prevention of heart attack and strokechest pain from heart problems (angina)

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High Blood Pressure Heart Conditions Heart Failure

How it works

Blocks L-type calcium channels in vascular smooth muscle and cardiac tissue, causing vasodilation and reduced cardiac contractility, while inhibiting angiotensin-converting enzyme (ACE) to prevent angiotensin II formation, thereby reducing peripheral vascular resistance and blood pressure through complementary mechanisms.

Prescription Required

You need a doctor's prescription to buy this drug.

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What to watch out for

Only buy Coveram from licensed pharmacies — fake blood pressure medicines are common from roadside or unregistered sellers in Nigeria. Never stop this medicine suddenly because you feel better — high blood pressure is a silent killer and needs lifelong management. Check your blood pressure regularly at a pharmacy or clinic to make sure the medicine is working.

Common Side Effects

Swelling of the ankles or feet
feeling dizzy or lightheaded
headache
dry cough (this is common with Perindopril and usually not dangerous)
feeling tired or weak

Serious Side Effects

Severe swelling of the face
lips
tongue or throat that makes it hard to breathe (this is an emergency — go to the hospital immediately)
chest pain or irregular heartbeat
signs of kidney problems like passing very little urine or swelling all over the body.

Drug Interactions

Avoid taking potassium supplements or salt substitutes that contain potassium, as Perindopril can raise potassium levels dangerously. NSAIDs like ibuprofen (e.g. Brufen) can reduce the blood pressure-lowering effect and harm your kidneys if used regularly. Alcohol can make dizziness and low blood pressure worse, so limit your intake.

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Pregnancy & Breastfeeding Warning

This drug is NOT safe during pregnancy — it can seriously harm or even kill your unborn baby, especially in the second and third trimesters. If you are pregnant, planning to become pregnant, or breastfeeding, tell your doctor immediately.

Who Should NOT Take This

People allergic to Amlodipine
Perindopril
or any ACE inhibitor. People who have ever had swelling of the face or throat (angioedema) from a blood pressure medicine. People with very low blood pressure
severe kidney disease
or narrowing of the heart valve (aortic stenosis). Diabetic patients already taking Aliskiren should avoid this drug.

How to Store

Store in a cool, dry place away from direct sunlight and heat — Nigeria's hot weather can damage medicines left in cars or near windows. Keep the tablets in their original pack and away from children.

For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.