How do you take Amlodipine (Amlodipine Besilate); Perindopril; Indapamide?

Take one tablet once a day, preferably in the morning before food. Swallow the tablet whole with a glass of water — do not crush or chew it. Your doctor will decide whether you need the lower strength (5/1.25/5 mg) or the higher strength (10/2.5/5 mg) based on how well your blood pressure is controlled.

What are the side effects of Amlodipine (Amlodipine Besilate); Perindopril; Indapamide?

Dizziness or lightheadedness (especially when you stand up quickly), swelling of the ankles or feet, dry cough, headache, feeling tired or weak

Who should not take Amlodipine (Amlodipine Besilate); Perindopril; Indapamide?

People allergic to Amlodipine, Perindopril, Indapamide, or any similar medicines (ACE inhibitors, sulfonamide-related drugs), pregnant or breastfeeding women, people with severe kidney or liver problems, people with very low blood pressure, people who have ever had swelling of the face or throat from using blood pressure medicines before, and people with low potassium levels.

Prescription

Antihypertensive (combination of Calcium Channel Blocker, ACE Inhibitor, and Diuretic)

Amlodipine; Perindopril; Indapamide

Q: What is Amlodipine (Amlodipine Besilate); Perindopril; Indapamide used for?

High blood pressure (hypertension), especially when one or two medicines alone are not enough to control it

Last reviewed June 2026

Who is this for?

What is this drug?

This is a combination medicine containing three active ingredients — Amlodipine (which relaxes blood vessels), Perindopril (which helps blood vessels stay open and reduces strain on the heart), and Indapamide (a water pill that helps your body get rid of extra salt and water). Together, they work to lower high blood pressure more effectively than any single drug alone.

What is it used for?

High blood pressure (hypertension)especially when one or two medicines alone are not enough to control it

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Heart Failure High Blood Pressure

How it works

Blocks L-type calcium channels in vascular smooth muscle causing vasodilation; inhibits angiotensin-converting enzyme (ACE) to reduce angiotensin II-mediated vasoconstriction and aldosterone secretion; inhibits sodium reabsorption in the distal convoluted tubule, promoting natriuresis and reducing intravascular volume.

Prescription Required

You need a doctor's prescription to buy this drug.

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What to watch out for

Only buy this medicine from a licensed pharmacy — do not purchase from roadside vendors or unregistered shops, as fake blood pressure drugs are common in Nigeria. Do not stop taking this medicine on your own even if you feel fine, because high blood pressure often has no symptoms but can cause stroke or heart attack. Check your blood pressure regularly and keep all your doctor's appointments.

Common Side Effects

Dizziness or lightheadedness (especially when you stand up quickly)
swelling of the ankles or feet
dry cough
headache
feeling tired or weak

Serious Side Effects

Swelling of the face
lips
tongue
or throat that makes it hard to breathe (this is an emergency — go to the hospital immediately)
very fast or irregular heartbeat
fainting or severe dizziness that does not go away

Drug Interactions

Avoid taking potassium supplements or potassium-containing salt substitutes without your doctor's knowledge, as this combination already affects potassium levels. NSAIDs like ibuprofen (commonly bought over-the-counter in Nigeria) can reduce the blood pressure-lowering effect and affect your kidneys — talk to your doctor before using them regularly. Avoid drinking alcohol as it can increase dizziness and cause your blood pressure to drop too low.

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Pregnancy & Breastfeeding Warning

This medicine is NOT safe during pregnancy — it can seriously harm your unborn baby, especially in the second and third trimesters — and it is not recommended during breastfeeding. If you become pregnant or plan to become pregnant, stop taking it and see your doctor immediately.

Who Should NOT Take This

People allergic to Amlodipine
Perindopril
Indapamide
or any similar medicines (ACE inhibitors
sulfonamide-related drugs)
pregnant or breastfeeding women
people with severe kidney or liver problems
people with very low blood pressure
people who have ever had swelling of the face or throat from using blood pressure medicines before
and people with low potassium levels.

How to Store

Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid storing near windows or in your car. Keep the tablets in their original pack and always keep them out of reach of children.

For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.