How do you take Amlodipine (Amlodipine Besilate); Indapamide?

Take one tablet once a day, preferably in the morning. Swallow it whole with a glass of water — do not crush, chew, or break the tablet because it is a modified-release type designed to release the drug slowly. You can take it with or without food. Your doctor will decide which strength is right for you.

What are the side effects of Amlodipine (Amlodipine Besilate); Indapamide?

Swelling of the ankles or feet, dizziness or feeling lightheaded, headache, feeling tired or weak, needing to urinate more often (especially at the beginning)

Who should not take Amlodipine (Amlodipine Besilate); Indapamide?

People allergic to Amlodipine, Indapamide, or sulfonamide-related drugs. People with severe liver or kidney problems. People with very low blood pressure. People with low potassium levels in their blood. People with severe heart failure or who recently had a heart attack with unstable heart function.

Prescription

Antihypertensive (Calcium Channel Blocker + Diuretic combination)

Amlodipine; Indapamide

Q: What is Amlodipine (Amlodipine Besilate); Indapamide used for?

High blood pressure (hypertension), especially when one drug alone is not enough to control your blood pressure

Last reviewed June 2026

Who is this for?

What is this drug?

This is a combination drug containing Amlodipine (a calcium channel blocker) and Indapamide (a water pill/diuretic). They work together to relax your blood vessels and remove extra water and salt from your body, which helps lower high blood pressure.

What is it used for?

High blood pressure (hypertension)especially when one drug alone is not enough to control your blood pressure

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High Blood Pressure

How it works

Blocks L-type calcium channels in vascular smooth muscle and cardiac tissue, causing vasodilation and reducing peripheral vascular resistance, while indapamide inhibits sodium reabsorption in the distal convoluted tubule, promoting natriuresis and reducing blood volume to synergistically lower blood pressure.

Prescription Required

You need a doctor's prescription to buy this drug.

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What to watch out for

Only buy Natrixam from licensed pharmacies — do not buy from roadside sellers or open markets as fake drugs are common. Do not stop taking this medicine suddenly because your blood pressure can spike dangerously — always consult your doctor before stopping. Check your blood pressure regularly at a pharmacy or clinic to make sure the drug is working well for you.

Common Side Effects

Swelling of the ankles or feet
dizziness or feeling lightheaded
headache
feeling tired or weak
needing to urinate more often (especially at the beginning)

Serious Side Effects

Severe dizziness or fainting (your blood pressure may have dropped too low)
irregular or fast heartbeat
signs of severe allergic reaction such as swelling of the face
lips or difficulty breathing — go to the hospital immediately if any of these happen.

Drug Interactions

Avoid taking this drug with other blood pressure medicines without your doctor's guidance, as your blood pressure may drop too low. Be careful with NSAIDs like ibuprofen (Brufen) as they can reduce its effectiveness and affect your kidneys. Avoid drinking alcohol as it can increase dizziness and further lower your blood pressure.

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Pregnancy & Breastfeeding Warning

This drug is not safe during pregnancy or breastfeeding — if you are pregnant, planning to become pregnant, or breastfeeding, tell your doctor immediately so they can switch you to a safer option.

Who Should NOT Take This

People allergic to Amlodipine
Indapamide
or sulfonamide-related drugs. People with severe liver or kidney problems. People with very low blood pressure. People with low potassium levels in their blood. People with severe heart failure or who recently had a heart attack with unstable heart function.

How to Store

Store in a cool, dry place away from direct sunlight and heat — Nigerian weather can be very hot, so avoid keeping it near windows or in your car. Keep it in its original pack and far away from children.

For information only — not medical advice. Always talk to a doctor or pharmacist before changing your medication.